Drug development Ion chromatography

an ion chromatography system used detect , measure cations such sodium, ammonium , potassium in expectorant cough formulations.

there has been growing interest in application of ic in analysis of pharmaceutical drugs. ic used in different aspects of product development , quality control testing. example, ic used improve stabilities , solubility properties of pharmaceutical active drugs molecules used detect systems have higher tolerance organic solvents. ic has been used determination of analytes part of dissolution test. instance, calcium dissolution tests have shown other ions present in medium can resolved among , calcium ion. therefore, ic has been employed in drugs in form of tablets , capsules in order determine amount of drug dissolve time. ic used detection , quantification of excipients or inactive ingredients used in pharmaceutical formulations. detection of sugar , sugar alcohol in such formulations through ic has been done due these polar groups getting resolved in ion column. ic methodology established in analysis of impurities in drug substances , products. impurities or components not part of drug chemical entity evaluated , give insights maximum , minimum amounts of drug should administered in patient per day.